Cholesterol is an essential component of the mammalian plasma membrane involved in diverse cellular processes.Our recent quantitative imaging analysis using ratiometric cholesterol sensors showed that the available cholesterol concentration in the inner leaflet of the plasma membrane (IPM) is low in unstimulated cells and increased in a stimulus-sp
Multi-attribute decision-making (MADM) technique has been widely utilized in many domains, including management, economics, and other disciplines.It plays a significant role in the mainstream of decision science.Its main process is to rearrange available choices and select the optimal option out of a group of options based on nordic forge rounding
The study investigates the modeling of a generalized speech portrait of a blog-discourse subject in the speech space of the German military blogosphere.The relevance of the work lies in the development of a methodology for modeling a speech portrait of a virtual linguistic personality, behind the mask of which is a real person, actively participati
Non-metastatic castration resistant prostate cancer (nmCRPC) is defined as a disease state withlack of radiographic evidence of metastatic disease, a confirmed rising PSA level on continuous ADT and maintaining a castrate level of testosterone following stedy stand aid definitive therapy.Prior to the publication of PROSPER, SPARTAN and ARAMIS, no t
The retinal pigment epithelium (RPE) is a neural monolayer lining the back of the eye.Degeneration of the RPE leads to severe vision loss in, so far incurable, diseases such as age-related macular degeneration and some forms of retinitis pigmentosa.A promising future replacement therapy may be autologous iris epithelial cell transdifferentiation in